Clinical Applications of TPE
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How TPE can offer support for your body
Therapeutic Plasma Exchange (TPE) has long been used in hospital medicine for serious immune and neurologic conditions and is now being explored more broadly in longevity and complex chronic care.
By removing a portion of plasma — where many inflammatory and immune-active molecules circulate — TPE works upstream at the level of the body’s internal environment.
Clinical applications being studied:
Neurocognitive & brain health
TPE may help reduce circulating inflammatory and protein factors associated with cognitive decline, brain fog, and certain neurodegenerative processes.
Autoimmune & inflammatory conditions
By lowering levels of circulating autoantibodies and inflammatory mediators, TPE may support individuals experiencing immune dysregulation and chronic inflammation.
Post-viral syndromes & long COVID
Persistent immune activation and inflammatory signaling are thought to contribute to lingering symptoms; TPE is being explored as a way to help calm this overactive response.
Longevity & “inflammaging”
Aging is closely linked with low-grade, chronic inflammation. Some longevity-focused individuals use TPE as part of a broader physician-guided strategy to reduce systemic inflammatory load.
A true
foundational reset
Therapeutic Plasma Exchange offers a powerful, upstream approach by directly removing a portion of the plasma that carries inflammatory proteins, autoantibodies, immune complexes, and certain protein-bound environmental toxins.
Emerging research and clinical experience suggest that a series of physician-guided TPE treatments may also support:
- Improvement in biomarkers linked to aging, cardiovascular risk, and cognitive function
- Reduction in symptom severity for some autoimmune conditions
- Removal of certain environmental toxins
- Support for individuals experiencing post-viral syndromes, including Long COVID
- Slowing of early neurodegenerative changes in select patients
- Improvements in energy, resilience, and overall physiologic function
TPE is well-established & used
across the world
TPE is generally well-tolerated when performed under the proper medical supervision of our providers. While not a cure-all, it can serve as a meaningful reset of the internal environment, creating more favorable conditions for recovery and long-term health optimization.
“I've recently completed my series of six TPE treatments. I've been through three years of chronic fatigue syndrome symptoms. I haven't felt this good in years — no fatigue, no lethargy, just feeling good. I can focus mentally and be my usual, productive self. I am so grateful for this change. Grossman Wellness Center has so many innovative treatments that have allowed me to have optimal results for my health and well-being.”
-BB, age 66
Reach out for an appointment Curated care starts here
Whether it’s exploring one of our specialty programs or considering our innovative therapeutic plasma exchange, our team will curate a plan tailored to your biology and your goals.